“通利大肠”对慢性阻塞性肺疾病模型大鼠肺功能及血气的影响

Influences of relaxing large intestine therapy on lung function and blood gas in rat model of chronic obstructive pulmonary diseases

目的观察"通利大肠"对慢性阻塞性肺疾病(COPD)模型大鼠肺功能及血气的影响,探讨COPD"从肠论治"的效应机制。方法采用气管注脂多糖加熏香烟联合造模方法建立COPD大鼠模型,随机分为正常组、模型组、治肺组、治肠组及肺肠同治组。正常组、模型组灌胃生理盐水,各给药组灌胃相应中药,连续14d。检测动物肺功能及血气分析相关指标。结果与正常组比较,模型组大鼠用力肺活量(FVC)、第0.3秒用力呼气容积(FEV0.3)、FEV0.3/FVC、用力中期呼气流速(FEF25-75)、最大呼气中期流速(MMF)、用力最大呼气流速(PEF)及动脉血酸碱度(pH)、氧分压(PaO2)、氧饱和度(SaO2)均降低(P<0.01或P<0.05),二氧化碳分压(PaCO2)升高(P<0.01)。与模型组比较,治肠组肺功能及血气显著改善(P<0.05)。与治肺组比较,肺肠同治组肺功能及血气进一步改善(P<0.05)。结论通利大肠,或在治肺的基础上增加通利大肠,均能增加对COPD模型大鼠肺功能及血气的改善程度。

Objective To observe the influences of relaxing large intestine therapy on lung function,blood gas in rat model of chronic obstructive pulmonary diseases（COPD） ,and investigate the effective mechanism of treating COPD based on intestines.Method The rat model of COPD was established by applying intratracheal injection of LPS and smoking,and then the rats were randomly divided into the normal group,model group,lung group,intestine group and lung-intestine group.The normal group and model group were given normal saline solution intragastrically and other groups were given relevant medicinals for 14 days,respectively.The indexes of lung function and blood gas were detected.Result In the model group,compared with the normal group,the indexes of FVC,FEV 0.3,FEV 0.3 /FVC,FEF25-75,MMF and PEF,and arterial pH,PaO 2,SaO 2 decreased,and PaCO 2 increased（P0.01 or P0.05） .The lung function and indexes of blood gas were improved significantly in the intestine group compared with the model group（P0.05） ,and improved further in the lung-intestine group compared with the lung group（P0.05） .Conclusion The relaxing large intestine therapy or this therapy combined with treatment of lung can improve lung function and blood gas indexes in rat model of COPD.