摘要
目的观察补肺通络方对慢性阻塞性肺疾病(COPD)模型大鼠的保护作用,为进一步探讨其对COPD气道重塑的影响作基础。方法采用烟熏加气管内注入脂多糖法复制COPD大鼠模型,分组观察补肺通络方对COPD模型大鼠的体质量、温水游泳时间、呼吸频率及肺功能FEV0.3/FVC%、MMF、CL、Ri、Re、PEF的影响。结果补肺通络方可提高COPD模型大鼠体质量增幅,减慢其呼吸频率,延长其温水游泳时间,使其FEV0.3/FVC%、MMF、CL升高,使Ri、Re降低。结论补肺通络方可有效改善COPD模型大鼠多项肺功能指标,改善其营养状态,提高其活动能力,对COPD模型大鼠起一定保护作用。
Objective To observe the role of Bufeitongluo formula in proecting Chronic obstructive pulmonary disease in rats. Methods COPD rats was induced by cigarette smoking inhalation and intratracheal LPS exposure. The effects of Bufeitongluo formula on COPD rats were approached by observing general status( such as body weight,movement and respiration,et al) ,pulmonary function ( FEV0. 3 /FVC% 、MMF、CL、Ri 、Re、PEF) was detected. Results After Bufeitongluo formula treatment,the weight of COPD rats increased,the movement improved,FEV0. 3/ FVC% 、MMF and CL of airway in COPD rats increased,while Ri and Re decreased. Conclusion Bufeitonglu formula could significantly increase pulmonary function of COPD rats,improved the movement activity of COPD rats.
出处
《中国临床保健杂志》
CAS
2010年第4期374-377,共4页
Chinese Journal of Clinical Healthcare
基金
安徽省卫生厅名老中医工作室建设项目
关键词
肺疾病
慢性阻塞性
补肺
通络
模型
动物
Pulmonary disease
chronic obstructive
Reinforcing lung Dredging collaterals
Models
animal