摘要
目的寻求一种适宜的石棉表面改性剂。方法用不同浓度的混合稀土或柠檬酸铝溶液浸泡温石棉１小时后，再将其与人胚肺（ＨＥＬ）细胞共同孵育，测定ＨＥＬ细胞的谷胱甘肽（ＧＳＨ）含量。结果随着石棉剂量的增加或染毒时间的延长，ＨＥＬ细胞的ＧＳＨ含量明显降低。经混合稀土或柠檬酸铝预处理的石棉，其所诱导的ＨＥＬ细胞ＧＳＨ下降的程度明显减弱。结论用混合稀土或柠檬酸铝预处理温石棉，均可降低温石棉对ＨＥＬ细胞的毒性作用。
Objective To
seek for an ideal chemical for surface modification of asbestos. Methods After being soaked in
mixed rare earths or aluminium citrate solutions at different concentrations for 1 hour,
chrysotile were incubated with human embryo lung (HEL) cells. Then, the levels of glutathione
in HEL cells were determined. Results Chrysotile caused dosedependent decreases of
glutathione level in HEL cells, but the compoundspretreated chrysotile induced less decreases
of glutathione level than the native chrysotile. Conclusion The pretreatment of chrysotile with
mixed rare earths or aluminium citrate might reduce the cytotoxicity of chrysotile.
出处
《中国职业医学》
CAS
1999年第3期4-6,共3页
China Occupational Medicine
