海洛因依赖并周围神经病变相关影响因素分析

ANALYSIS OF INFLUENCING FACTORS ON HEROIN DEPENDENCE ACCOMPANIED WITH PERIPHERAL NEUROPATHY

目的:了解海洛因依赖并周围神经病变发病状况及其相关影响因素,为疾病的预防控制提供科学依据。方法:将285例海洛因依赖者作为研究对象,分为病变组和非病变组;用t检验及χ2检验筛选出与周围神经病变有关的影响因素;用多因素Logistic回归分析比较各种吸毒行为因素对周围神经病变发病的影响。结果:毒品使用方式(P<0.001)、毒品使用种类(P<0.001)、注射器使用消毒情况(P<0.001)、共用注射器情况(P<0.001)、HIV感染情况(P<0.001)、毒品使用年限(P<0.01)、静脉注射毒品年限(P<0.01)、日毒品使用量(P<0.05)等因素在两组间比较差异有显著性;多因素Logistic回归分析提示,毒品使用方式(P<0.05)、毒品使用种类(P<0.01)、毒品使用年限(P<0.05)、日毒品使用量(P=0.01)、注射器使用消毒情况(P<0.05)、HIV感染情况(P<0.01)与周围神经病变相关。结论:海洛因依赖并周围神经病变是多种影响因素综合作用的结果,其中毒品使用方式、毒品使用种类、注射器使用消毒情况、HIV感染情况、毒品使用年限、日毒品使用量是危险影响因素。

Objective： To understand the situation of heroin dependence accompanied with peripheral neuropathy and its related factors so as to provide scientific data for the disease prevention and control. Methods：A total of 285 heroin dependent patients were enrolled and divided into two groups, one group was accompanied with peripheral neuropathy and the other one without the disease. The drug abuse behavior factors in the two groups were compared to see if these factors had influence on peripheral neuropathy. T test and χ^2 test were used to screen out the influencing factors related to peripheral neuropathy and multiple factors Logistic regression was used to analyze drug abuse behavior factors on peripheral neuropathy. Results. ：Differences were observed between the two groups in routes of drug taking（P 〈 0. 001）, types of drugs used （ P 〈 0. 001 ）, degermation of syringes （ P 〈 0. 001 ）, needle sharing （ P 〈 0. 001 ）, HIV infections （P 〈 0. 001 ）, years of drug use （P 〈 0. 01 ）, years of iv drug injection （ P 〈 0. 01 ） and daily dose of drug use（P 〈0. 05）. Multiple factors Logistic recession analysis showed that oeripheral neuropathy was positively correlated with routes of drug taking （P 〈 0. 05）, types of drugs used （P 〈 0. 01 ）, years of drug use（P 〈0. 05）, daily dose of drug use（P =0. 01）, degermation of syringes（P 〈0. 05） and HIV infections （ P 〈 0. 01 ）. Conclusion ： Heroin dependence accompanied with peripheral neuropathy is caused by complex factors, including routes of drug taking, types of drugs used, degermation of syringes, HIV infections, years of drug use and daily dose of drug use, which are risk factors.