尖笔直写成形工艺与应用研究

Research on Forming Technology and Application of Micro-Tip Direct Writing

生命体微结构特征的构建是组织工程学的重要任务,这对成形技术提出了技术挑战。以管状血管支架成形为代表,目前的成形工艺在精度上尚待提高,且无法直接使用生物材料成形。尖笔直写技术以压缩气体提供微输运动力,用微尖保证成形精度,且对材料的生物活性没有影响,从而使制造具有微米级结构特征的三维支架成为可能。深入研究了该成形工艺,以混合糖制备了单层薄壁管支架和多级管支架,并用数值模拟的方法分析了工艺参数对尖笔直写技术的影响。

The construction of micro-structural characteristics is an important task of tissue engineering, which challenges the current forming technology. Like the fabrication of tubular blood vessel scaffold, the current forming technology still needs to be improved in precision and cannot directly use biological material for forming. Tip-Pen Direct Writing （TPDW） technology uses compressed air to provide micro-transport drive and micro-tip to ensure shaping accuracy and it has no impact on material biological activity. Thereby MTDW makes the manufacturing of three dimensional scaffolds with micron-level structural characteristics possible. This paper conducted a deep study of this technology. Single layer and multi-level tubular scaffold were made by sugar mixture. The impact of processing parameters over this technology was analyzed by numerical simulation.