摘要
目的:探讨三七花总皂苷对动脉粥样硬化(AS)大鼠血脂、血液流变学的影响。方法:采用维生素D高脂饲料法复制动脉粥样硬化大鼠模型,观察三七花总皂苷对动脉粥样硬化大鼠血脂、血液流变学指标的影响。结果:三七花总皂苷可显著降低动脉粥样硬化大鼠血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL),升高高密度脂蛋白(HDL)(P<0.05);显著降低动脉粥样硬化大鼠全血黏度(高、中、低切),血浆黏度,红细胞压积(P<0.05)。结论:三七花总皂苷可改善动脉粥样硬化大鼠血脂水平和血液流变学,对动脉粥样硬化具有一定的防治作用。
Objective: To observe the effect of total saponins of flos Notoginseng on blood lipid and hemorheology in atherosclerosis rats.Method: The AS model of rat was made by freeing high grease food,and the level of serum lipid and blood rheology were teste.Result: Total Saponins of Flos Notoginseng could obviously lower TG,TC,LDL and blood viscosity,and increased HDL.It could improve the degree of hepaticsteatosis and hepatocellular necrosis of rat.Conclusion: Total Saponins of Flos Notoginseng can adjust fatty substance metabolism and lower blood lipid and improve hemorrheology of atherosclerosis rats,and has therapentic effect for atherosclerosis.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第12期162-164,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西自然科学基金项目(2010GXNSFA013255)
关键词
三七花总皂苷
动脉粥样硬化
血脂
血液流变学
大鼠
Total Saponins of Flos Notoginseng
Atherosclerosis
blood lipid
hemorrheology
rat