普罗布考对颈动脉粥样硬化的影响60例临床研究被引量：2

Effects of Probucol on Carotid Atherosclerosis in 60 Cases

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摘要目的:观察普罗布考对颈动脉粥样硬化的作用。方法:颈动脉粥样硬化患者60例,随机分普罗布考组和对照组,各30例,普罗布考组患者接受普罗布考治疗(口服0.25 g/次,2次/d)3个月,对照组患者不接受降脂或抗氧化治疗。分别于治疗前后经彩色多普勒技术测定颈动脉斑块厚度,检测血氧化低密度脂蛋白(ox-LDL)水平。结果:治疗后,普罗布考组患者颈动脉斑块厚度明显减小,血ox-LDL水平降低。结论:普罗布考可能通过降低血ox-LDL水平途径,减轻颈动脉粥样硬化程度。 Objective： To observe the effects of probucol on carotid atherosclerosis.Methods： Sixty patients with carotid atherosclerosis were randomly divided into two groups.Cases in probucol group（n=30） have been orally given 0.25 gram of probucol twice a day for 3 months and the ones in control group（n=30） have not been treated with any lipid-lowering agents or antioxidants therapy.The thickness of carotid artery speckles and the plasma level of oxidized low-density lipoprotein（ox-LDL） were examined before and after the treatment.Results： The thickness of the carotid artery speckles and the plasma level of ox-LDL of patients in the probucol group were significantly decreased compared with that in the control group.Conclusion： Probucol could ameliorate atherosclerosis on the carotid arteries,perhaps by decreasing the plasma level of ox-LDL.

作者吴乐黎红华武强王晓昆

机构地区广州军区武汉总医院神经内科广州军区武汉总医院医学实验中心

出处《神经损伤与功能重建》 2010年第5期352-354,共3页 Neural Injury and Functional Reconstruction

关键词普罗布考颈动脉粥样硬化氧化低密度脂蛋白 probucol carotid atherosclerosis oxidized low-density lipoprotein

分类号 R741 [医药卫生—神经病学与精神病学] R741.05 [医药卫生—神经病学与精神病学]

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