血清CysC联合RBP检测在诊断早期肾损伤中的应用价值

RBP serum CysC joint diagnosis of early detection of kidney injury in the application of value

目的:探讨联合检测血清胱抑素C(CystatinC,CysC)和视黄醇结合蛋白(Retinol-Binding Protein,RBP)在早期诊断肾损伤的应用价值。方法:对照组选择50例,为健康体检无肾脏病史且尿蛋白定性为阴性者;试验组选择36例尿蛋白定性为弱阳性,肾穿刺活检确诊为早期肾损伤的患者。采用免疫透射比浊法分别测定血清CysC和RBP的浓度,并测定血清肌酐(Crea)及尿素(Urea)的浓度,并进行相关的统计学分析。结果:CysC的浓度对照组为(1.12±0.23)mg/L,试验组为(1.78±0.46)mg/L;RBP的浓度对照组为(47.19±14.34),试验组为(85.87±21.64);肌酐的浓度对照组为(60.8±16.17)μmol/L,试验组为(72.5±45.7)μmol/L。尿素的浓度对照组为(5.35±1.46)mmol/L,试验组为(6.21±2.39)mmol/L。结论:联合检测血清CysC和RBP对诊断早期肾损伤具有较高的临床应用价值。

Objective Detection of serum cystatin C（CystatinC,CysC）and retinol binding protein（Retinol-Binding Protein,RBP）in early diagnosis of renal injury in value.Methods 50 patients in control group,the hospital history and physical examination without kidney proteinuria defined as negative;experimental group select 36 cases classified as weak positive urine protein,renal biopsy diagnosed patients with early renal injury.By immune turbidimetry of serum CysC were measured and the concentration of RBP,and serum creatinine（Crea）and urea（Urea）concentration,and the associated statistical analysis.Results CysC concentration of the control group（1.12±0.23）mg/L,the experimental group（1.78±0.46）mg/L;RBP concentration of the control group（47.19±14.34）,experimental group（85.87±21.64）;creatinine concentration of the control group（60.8±16.17）μmol/L,the experimental group（72.5±45.7）μmol/L.The concentration of urea in control group（5.35±1.46）mmol/L,the experimental group（6.21±2.39）mmol/L.Conclusion The detection of serum CysC and RBP on the diagnosis of early kidney damage with high clinical value.