子宫内膜异位症及子宫腔肌症患者的血清CA_(125)测定

SERUM CA_(125) ASSAYS IN PATIENTS WITH ENDOMETRIOSIS AND ADENOMYOSIS

目的：探讨血清CA125测定对子宫内膜异位症（异位症）及子宫腺肌症的诊断价值。方法：采用免疫放射方法（IRM）对30例异位症，24例腺肌症及子宫肌瘤、卵巢囊肿、正常妇女血CA125水平进行测定。结果：异位症组阳性率56．66％，均值为（65．87±59．90）ku／L，腺肌症组阳性率87.50％，均值为（101.86±68.21）ku/L。子宫肌瘤组、卵巢囊肿组及正常组阳性率分别为10.34％、9.09％及6.67％，均值分别为（13．14±12．99）ku／L、（16．51±11．12）ku／L及（11．92±9．93）ku／L。异位症组和腺肌症组均值及阳性率明显高于其它3组（P＜0.05），而腺肌症组又较异位症组高（P＜0．05）。异位症患者随病程进展CA125增高，Ⅲ/Ⅳ期患者较Ⅰ／Ⅱ期患者明显增高（P＜0．05）。异位症患者术后一周血清CA125明显下降（P＜0．05）。结论：血清CA125测定对子宫腺肌症及晚期异位症有辅助诊断价值，且有助于与子宫肌瘤和卵巢囊肿的鉴别。

To investigate the value of serum CA125 assays in diagnosis of endometriosis and adeno-myosis. Methods: Thirty consecutive patients with endometriosis, twenty-four with adenomyosis and other six-ty-six with leiomyoma of uterus, ovarian cyst and normal women were studied. The serum CA125 level were de-termined by immunoradiometric assay (IRMA). Result: The mean CA125 levels (x ± s ) of the above five groups were (65. 87±59. 90) ku/L, (101. 86±68. 21 ) ku/L, (13. 14±12. 99) ku/L, (16. 51±11. 12) ku/Land (11. 92± 9. 93) ku/L respectlvely. The CA125 positive rates (CA125≥35 ku/L) for the above five groups were 56. 66%, 87. 50%, 10. 34%, 9. 09% and 6. 67% respectively. The mean CA125 level and positive rates in patients with endometrosis and abenomyosis were signlficqntly higher than those in the other three groups (P < 0. 01 ). The CA125 levels in patients with endometriosis were correlated with clinical stage; the levels in patients with stage Ⅲ/ Ⅳ were signlficantly higher than those with stage Ⅰ /Ⅱ (P <0. 05). The mean CA125 levels pa-tients with endometriosis decreased signficantly in one week of postoperation (P <0.05). Conclusion: Serum CA125 assay is of great assistance to the digtiosis of uterine adenomyosis and advanced endometriosis as well as to the differential diagnosis with leiomyoma and ovarian cyst.