国产丙种球蛋白预防肾病综合征患儿医院感染的观察

Preventive efficiency of IVIgG on nosocomial infection in the children with nephrotic syndrome

为观察静脉用丙种球蛋白（ＩＶＩｇＧ）对肾病综合征（ＮＳ）患儿医院感染（ＮＩ）的预防效果，将５４例ＮＳ患儿随机分为两组，观察组２２例，对照组３２例。全部病例按ＮＳ治疗常规治疗。观察组加用ＩＶＩｇＧ１００～３００ｍｇ·ｋｇ－１·ｄ－１，以５％的葡萄糖溶液使其浓度稀释成３％，静脉滴注，疗程２～３ｄ。结果：观察组患儿ＮＩ的发生率为１３６３％，明显低于对照组的４６８８％（Ｐ＜０．０５）；住院时间由对照组的（６４５０±１８５２）ｄ缩短为（２７３３±１５５１）ｄ（Ｐ＜０．０５）。提示ＩＶＩｇＧ能改善ＮＳ患儿免疫状态，在一定程度上有效地预防医院感染。

In order to study the preventive efficiency of IVIgG on nosocomial infection(NI), 54 cases of the children with nephrotic syndrome(NS) were randomly divided into 2 groups, test group( n=22 ) and control group( n =32). Routine treatment was adopted to all cases. Besides the routine treatment, the test group was injected with IVIgG(100～300mg·kg -1 ·d -1 ) for 2～3 days. The results showed that the NI rate of test group(13.6%) was significantly lower than that of the control(46.88%) ( P <0.05), and the hospital days of the test group(27.33±15.51)d was significantly shorter than that of the control(64.50±18.52)d ( P <0.05). These suggest that IVIgG, as one of the ways to prevent NI, can improve the immune state and effectively prevent the NI in the children with NS.