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莽草酸对动脉粥样硬化大鼠血脂及血液流变学影响的实验研究 被引量:5

Experimental Studies on the Effect of Shikimic Acid on the Blood Lipid and Hemorrheology in Atherosclerosis Rats
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摘要 目的:探讨莽草酸对动脉粥样硬化(AS)大鼠血脂、血液流变学的影响。方法:采用高脂饲料复制动脉粥样硬化模型,观察莽草酸对动脉粥样硬化大鼠血脂、血液流变学指标的影响。结果:莽草酸可显著降低动脉粥样硬化大鼠血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)水平,升高高密度脂蛋白(HDL)水平(P<0.05),并能显著降低动脉粥样硬化大鼠全血黏度(高、中、低切)、血浆黏度和红细胞压积(P<0.05)。结论:莽草酸可改善AS大鼠血脂水平和血液流变学指标,对AS具有一定的防治作用。 Objective: To observe the effect of shikimic acid on blood lipid and hemorheology in atherosclerosis (AS) rats. Method: The AS model of rat was made by freeing high grease food, and the level of serum lipid and blood theology were tested. Result: Shikimic acid could obviously decrease TG, TC, LDL, hemotocrit, and blood viscosity, and increase HDL of atherosclerasis rats. Conclusion: Shikimic acid can adjust blood lipid and improve hemorrheo logy of atherosclerosis rats, and has therapentic effect for athemsclerosls.
出处 《中国药师》 CAS 2010年第10期1394-1396,共3页 China Pharmacist
基金 广西自然科学基金项目(编号:2010GXNSFA013255)
关键词 莽草酸 动脉粥样硬化 血脂 血液流变学 大鼠 Shikimic acid Atherosclerosis Blood lipid Hemorrheology Rat
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