甲亢性肝病患者血清检验指标改变的临床意义

The clinical significance of changed serum laboratory indexes in hyperthyroid hepatopathy patients

目的:探讨甲亢性肝病患者血清检验指标改变的临床意义。方法:分析108例甲亢性肝病(A组,肝功能异常组)的临床特点,并与91例新诊断甲亢患者(B组,肝功能正常组)相对照,比较两组患者一般情况、临床表现、肝功能相关指标和甲状腺功能指标。结果:肝功能异常组患者血清ALT、ALP、GGT、TT3、TT4水平明显高于肝功能正常组(P<0.05),TBA、TSH两组相比无明显差异(P>0.05)。结论:甲亢容易合并肝损害,肝损害的程度与年龄、病程及病情轻重密切相关,甲亢性肝病临床表现不典型,多发生于年龄较大、病情较重的患者。

Objective：To explore the clinical significance of changed serum laboratory indexes in hyperthyroid hepatopathy patients.Methods： Clinical feature of 108 patients with hyperthyroid hepatopathy were analyzed and 91 newly diagnosed hyperthyroidism were divided into group A（abnormal liver function group） and group B（normal liver function group）.The liver function-related markers（ALT,ALP,GGT,TBA） and the indicators of thyroid function（TT3,TT4,TSH） in two groups were analyzed.Results： The levels of serum ALT,ALP,GGT,TT3,TT4 in group A were significantly higher than those in group B（P0.05）,but TBA and TSH in two groups had no significant difference（P0.05）.Conclusion： Hyperthyroidism easily led to liver damage and the extent of liver damage was closely related with age,disease course and severity.Clinical feature of hyperthyroid hepatopathy is not typical.Of the patients with relatively old age and severe symptom,the incidence of hyperthyroid hepatopathy increases.