摘要
目的观察中药地黄、苏合香(地苏合剂)对四氯化碳(CCl4)致轻微肝性脑病(MHE)大鼠模型的治疗作用。方法采用灌胃给予CCl4致化学性肝损伤大鼠模型,通过开场实验和Morris水迷宫实验,观察地苏合剂低、中、高3个剂量组对模型鼠自发运动、空间记忆能力的影响,并检测肝脾及血液生化学指标;阳性药采用乳果糖。结果造模12周后发现MHE模型鼠的自发运动明显减少,Morris水迷宫空间记忆能力明显下降;服用地苏合剂12周后高剂量治疗组模型鼠的自发运动和空间学习记忆明显改善(P<0.01,P<0.05);同时血中丙氨酸氨基转移酶(ALT)和血氨(Amm)浓度明显低于未治疗组(P<0.05,P<0.01)。结论地苏合剂对轻微肝性脑病模型大鼠有明显的治疗作用。
Objective To assess the effects of rehmannia and storesin on minimal hepatic encephalopathy（MHE） in rat model.Methods MHE rat model was induced by carbon tetrachloride （CCl4） intragastric administration. The effects of rehmannia and storesin on spontaneous movement and learning and memory function of model animals were evaluated with open field test and Morris water maze in 3 dose groups. Lactulose was used in the positive group.Results The spontaneous movement and the spatial learning and memory ability of the model rats both improved significantly in the high dose group. Meanwhile,the serum level of alanine transarninase（ALT） and ammonia（Amm） also decreased in the high dose group.Conclusion Rehmannia and storesin has therapeutical effect on MHE rat model.
出处
《中国康复理论与实践》
CSCD
2010年第10期904-906,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金(30873390)
北京中医药科技项目(JJT2007-001)
科技部重大新药创制科技专项项目(2009ZX09303)
关键词
地黄
苏合香
轻微肝性脑病
行为学
丙氨酸氨基转氨酶
血氨
rehmannia
storesin
minimal hepatic encephalopathy
behavior
alanine transarninase
ammonia
