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高危与非高危儿童急性淋巴白血病免疫表型分析

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摘要 目的探讨高危与非高危急性淋巴白血病(ALL)免疫表型的特点,为临床治疗及判断预后提供指导。方法应用单克隆抗体和流式细胞仪对66例高危与73例非高危(ALL)骨髓白血病细胞免疫表型进行检测。结果高危ALL的淋巴系抗原阳性表达数与非高危组无差异。高危ALL伴髓系抗原阳性表达数明显高于非高危ALL(2=8.98,P<0.05);CD34、HLA-DR在两组间的表达差异无显著性。结论免疫表型有助于初发急性白血病的预后判断,ALL伴髓系抗原表达可作为一种高危因素。
出处 《广东医学》 CAS CSCD 北大核心 2010年第19期2560-2561,共2页 Guangdong Medical Journal
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  • 1王菊香,汤静燕,顾龙君,薛惠良,陈静,潘慈,叶辉,董璐.初诊急性淋巴细胞白血病患儿髓系抗原表达及临床意义[J].中国实用儿科杂志,2004,19(9):535-537. 被引量:6
  • 2吴学东,李春富,何岳林,杨明,张玉明,冯晓勤,藤志丽,孙树梅,钱新华.儿童急性淋巴细胞白血病南方ALL99方案临床疗效分析[J].中华儿科杂志,2005,43(12):890-893. 被引量:5
  • 3肖志坚,郝玉书.免疫表型分析与急性白血病诊断[J].中华血液学杂志,1997,18(1):53-54. 被引量:67
  • 4Copelan EA,Mc Guire EA.The biology and treatment of acute lymphoblastic leukemia in adult.Blood, 1995,85:1151
  • 5Uckun FM,Jaszez W,Ambrus JL,et al.Detailed studies on expression snd function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.Blood, 1988,71:13
  • 6Campana D, Janossy G, Bofill M, et al.Human B cell the bone marrow and peripheral lymphoid tissue.Journal of Immunology,1985,134:1524
  • 7Janossy G,Coustan-Smith E,Campana D,et al.The reliability of CyCD3 and CyCD22 antigen expression in the immuno diagnosis of acute leukemia,a study of 500 cases.Leukemia,1989,3:170
  • 8Aguikera RP,Guzman LR,Santiago NL, et al.Flow cytometic analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia. Am J Hematol,2001,68(2):69
  • 9KAMPS W A,BOKKERINK J P,HAHLEN K,et al.Intensive treatment of children with acute lymphoblastic leukemia according to ALL-BFM-86 without cranial radiotherapy:results of Dutch Childhood Leukemia Study Group Protocol ALL-7 (1988-1991)[J].Blood,1999,94(4):1226-1236.
  • 10SCHRAPPE M,REITER A,ZIMMERMANN M,et al.Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995[J].Leukemia,2000,14(12):2205-2222.

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