2-[[2'-氰基(1,1'-联苯基)-4-]甲基]巯基苯并噻唑的合成

Synthesis of 2-[[2'-cyano(1,1'-biphenylyl)-4-]methyl]mercaptobenzothiazole

目的研究2-[[2'-氰基(1,1'-联苯基)-4-]甲基]巯基苯并噻唑的合成方法及最佳条件。方法通过2-巯基苯并噻唑与2-氰基-4'-溴甲基联苯在氢氧化钾/N,N-二甲基甲酰胺体系中进行缩合反应,制得目标化合物。结果经检测确定目标化合物为2-[[2'-氰基(1,1'-联苯基)-4-]甲基]巯基苯并噻唑,其反应的最佳条件为温度80℃,时间1.5h,2-氰基-4'-溴甲基联苯、2-巯基苯并噻唑和KOH的物质的量之比为111.5。结论通过不同反应条件进行缩合反应可以合成一种新的苯并噻唑衍生物。

Objective To research the synthetic method and optimum reaction condition of 2-[[2＇-cyano（ 1,1＇-biphenyl） -4-]methyl]mercaptobenzothiazole. Methods The target compound was synthesized by the condensation of 2-mercapto-benzothiazole with 4-bromomethyl-2＇-cyanobiphenyl in N,N-dimethyl formamide in the presence of potassium hydroxide. The structure of the title compound was confirmed by EI-MS,1 H NMR,13 C NMR,IR and elementary analyses. Results The target compound was identified as 2-[[2＇-cyano（ 1,1＇-biphenylyl） -4-]methyl]mercaptobenzothiazole. The optimum reaction condition was 80 ？栬1. 5 hours and the mole ratio of 4-bromomethyl-2＇-cyanobiphenyl？？2-mercaptobenzothiazole and potassium hydroxide was 1：1：1. 5. Conclusion A kind of new benzothiazole derivative was synthesized by the condensation reaction under the different reaction conditions.