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己酮可可碱对类风湿关节炎疾病活动性指标的影响 被引量:3

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摘要 目的观察己酮可可碱注射液(潘通)对类风湿关节炎(RA)各项疾病活动性指标的影响及其可能的作用机制。方法将60例RA患者随机分为2组:2组均给予非甾体类消炎药+柳氮磺胺吡啶+甲氨蝶呤治疗,治疗组在此基础上给予潘通治疗,疗程4周。观察比较2组治疗前后关节肿胀指数、关节疼痛指数、HAQ、晨僵时间、急性时相反应物水平等疾病活动性指标的变化。结果经4周治疗,2组反映RA疾病活动性指标均有明显改善,其中治疗组关节疼痛指数、晨僵时间、HAQ、血沉、C反应蛋白改善较对照组更为显著(P均<0.01)。结论己酮可可碱治疗RA可能通过降低血液黏度、改善微循环动力学以及免疫抑制作用减轻炎症,缓解症状。
出处 《现代中西医结合杂志》 CAS 2010年第34期4406-4407,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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