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转录因子7样2基因rs290487多态性与安徽地区汉族人群多囊卵巢综合征的相关性

Association of TCF7L2 gene rs290487 polymorphism and polycystic ovarian syndrome in Hans in Anhui Province
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摘要 用TaqMan-MGB探针杂交和荧光定量PCR检测169例多囊卵巢综合征（PCOS）患者和95名正常对照者rs290487（C/T）的基因型,同时检测临床指标.结果 显示该位点多态性与安徽地区汉族人群PCOS的发病相关,C等位基因增加了PCOS发病的风险,CC基因型是胰岛素抵抗的危险基因型. One-hundred and sixty-nine women with polycystic ovarian syndrome （PCOS）and 95 healthy women were enrolled. All subjects were genotyped for rs290487 （ transcription factor 7-like 2 gene） by TaqManMGB probe hybridization assay. The results showed that polymorphism rs290487 had association with PCOS in Han people in Anhui area. The allele C was associated with the risk of PCOS. Genotype CC seems to be the risk factor of insulin resistance in PCOS patients.
作者 金国玺 毕娅欣 于磊 王佑民
机构地区 蚌埠医学院第一附属医院内分泌科 安徽医科大学第一附属医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2010年第10期868-870,共3页 Chinese Journal of Endocrinology and Metabolism
关键词 多囊卵巢综合征 转录因子7样2基因 胰岛素抵抗 Polycystic ovarian syndrome Transcription factor 7-like 2 gene Insulin resistance
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献10

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二级参考文献24

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中华内分泌代谢杂志
2010年 第10期

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