70例肺癌并发深静脉血栓患者临床分析

Clinical analysis of 70 patients with lung cancer associated with deep venous thrombosis

目的分析并发深静脉血栓的肺癌患者的临床特征、治疗情况,加深对此类患者的认识。方法对2002年10月至2009年3月在我院住院的70例并发深静脉血栓肺癌患者的临床特征、实验室检查、治疗等情况进行回顾性分析。结果 70例患者均为晚期。非小细胞肺癌54例(77.1%),小细胞肺癌16例(22.9%);腺癌42例(60%),鳞癌8例(11.4%),腺鳞癌4例(5.7%)。接受化疗患者57例(81.4%)。血栓发生的中位时间为确诊后3个月,下肢血栓占47.1%,54.3%患者D-二聚体增高。治疗后79.3%血栓症状有好转。化疗是影响肺癌并发深静脉血栓患者生存的独立因素。结论深静脉血栓在晚期、化疗、腺癌患者中常见,临床上应采取积极治疗措施。

Objective To learn more about patients with lung cancer associated with deep vein thrombosis（DVT） by analyzing the clinical characteristics and treatment. Methods Seventy hospitalized lung cancer patients associated with DVT in our hospital from October 2002 to March 2009 were enrolled. Their clinical characteristics, laboratory tests and treatment were analyzed. Results Among 70 patients, patients with adenocarcinoma type accounted for 60% , in which 81.4% received chemotherapy, and 100% advanced stage patients received chemotherapy. The median time of occurrence of thrombosis was 3 months after diagnosis.DVT affected the lower limbs in 47.1% of cases. 54.3% patients had elevated D-dimmer level. 79.3% patients＇ symptoms of thrombosis had been relieved after treatment. Chemotherapy was an independent factor for survival. Conclusions Deep vein thrombosis is common in patients in advanced cancer,who received chemotherapy and with adenocarcinoma. Aggressive treatment should be given to these patients.