油酸诱导大鼠肺水肿动物模型的建立

Establishment of Oleic Acid-Induced Animal Model of Pulmonary Edema in Rats

[目的]制备油酸诱导大鼠肺水肿的动物模型,便于进行肺水肿的发病机制和相关治疗的研究。[方法]将试验大鼠随机分为对照组和油酸组,尾静脉注射油酸0.2ml/kg,观察动物的体征变化及病理切片,确定大鼠肺水肿动物模型。[结果]油酸能引起大鼠肺水肿,其临床症状和病理变化明显。[结论]油酸诱发的肺水肿模型临床症状典型、方法简单、成本低、便于操作且重复性好,能为教学、临床、科研提供较为理想的动物模型。

[ Objective ] To establish an animal model of pulmonary edema in rats in order to serve the study on mechanisms and treatment of pulmonary edema. [ Methods] The white rats were randomly divided into control and ammonium chloride groups. The pulmonary edema was established by injecting oleic acid 0.2 ml/kg into the tail vein. The rats condition, pulmonary ratio and pathologic section were observed to i- dentify the pulmonary edema model. [ Result] The ammonium chloride could induce acute pulmonary edema and had its own character. [ Conclusion ] The model of the pulmonary edema induced by ammonium chloride is ideal. The symptom is obvious, and the animal model is feasible and economic.