摘要
目的研究母细胞性浆细胞样树突细胞肿瘤(BPDCN)的临床病理特点、免疫组化、诊断及鉴别诊断。方法报道1例BPDCN,并复习文献总结其临床病理学、免疫组化特征。结果组织形态学表现为肿瘤细胞弥漫分布,中等大小,细胞质少,核不规则,染色质细,核分裂多见,无坏死。免疫组化:肿瘤细胞CD123、CD56、CD43和S-100(+),少数细胞CD4、CD7和TdT(+),CD2、CD3、CD20、CD21、CD34、CD35、CD68、Pax-5、CD99、CD117和MPO(-)。结论 BPDCN是一种少见的淋巴造血系统高度侵袭性肿瘤,预后差,应注意与其他淋巴造血系统肿瘤相鉴别。
Objective To better define the clinicopathologic features of blastic plasmacytoid dendritic cell neoplasm （BPDCN）. Methods A case of BPDCN was observed by gross, morphology, immunohistochemical technique and review of literature. Results Morphologically, the lymph node showed diffuse effacement of architecture. The infiltrate comprised monotonous medium-sized cells with round, irregularly folded and convoluted nuclei, fine ehromatin, and a thin rim of light-staining cytoplasm. Immunohistoehemically, tumor cells were positive for CD123, CD56, CD43, S-100 protein, and CD4, CD7, TdT were weak staining while they were negative for CD2, CD3, CD20, CD21, CD34, CD35, CD68, Pax-5, CD99, CD117 and MPO. Conclusion BPDCN is a rare highly aggressive neoplasm of haematopoietic and lymphoid tissues. The differential diagnosis is necessary from other haematopoietic and lymphoid tumors.
出处
《诊断病理学杂志》
CSCD
2010年第5期346-348,共3页
Chinese Journal of Diagnostic Pathology
关键词
母细胞性
浆细胞样树突细胞
免疫组化
鉴别诊断
Blastic
Plasmacytoid dendritic cell
Immunohistochemistry
Differential diagnosis
