抗精神病药对血清细胞因子的影响

Effect of antipsychotic drugs on serum cytokines

目的：探讨抗精神病药对精神分裂症患者血清细胞因子的影响。方法：对４６例精神分裂症患者给予抗精神病药治疗６周，在治疗前后检测血清ＩＬ－６和ＴＮＦ－α水平，并采用阳性与阴性症状量表（ＰＡＮＳＳ）、副反应量表（ＴＥＳＳ）评估临床症状变化及药物副反应。结果：抗精神病药治疗后，血清ＩＬ－６水平显著下降，血清ＴＮＦ－α水平变化不显著。治疗前血清ＩＬ－６水平与ＰＡＮＳＳ阳性因子分显著正相关，而血清ＴＮＦ－α与ＰＡＮＳＳ总分无相关。血清ＩＬ－６减分率与药物最高剂量呈显著正相关，而血清ＴＮＦ－α减分率与药物剂量无相关。血清ＩＬ－６和ＴＮＦ－α减分率与ＴＥＳＳ无相关。结论：精神分裂症精神症状可能与细胞因子功能异常有关，抗精神病药可能因抑制ＩＬ－６的生成而起到免疫抑制作用。

Objective:To study the effect of antipsychotic drugs on serum cytokines in schizophrenic patients. Method:Serum IL 6 and TNF α were measured with ELISA in 46 schizophrenic patients,before and after treatment with antipsychotic drugs for six weeks.Clinical features were measured with PANSS and side effects rated with TESS. Results:The serum IL 6 level was significantly decreased after antipsychotics treatment but there was no significant change in the TNF α level.Scores of positive factors of PANSS correlated positively with pretreatment serum IL 6 level but not TNF α.The decrease in serum IL 6 level after treatment correlated positively with maximum dosage of antipsychotics reached.No significant relationship with TESS was detected for both cytokines. Conclusion:The current study demonstrates that schizophrenic psychosis is associated with cytokine dysfunction.