变应性鼻炎舌下免疫与综合治疗的疗效观察

Clinical Evaluation for SLIT of Atopic Rhinitis with Dermatophagoides Farinae Drops

目的评价舌下尘疫苗螨疫苗治疗变应性鼻炎的疗效及安全性。方法采用单纯舌下尘螨含服(38例)与舌下尘螨疫苗含服配合药物治疗(38例)对比的方法,对76例尘螨过敏的变应性鼻炎患者进行了6个月的临床观察。结果治疗后两组患者的症状和体征评分与治疗前比较,差异有统计学意义(P<0.05)。单纯舌下含服组总有效率为63.16%,综合治疗组总有效率为86.84%,差异有统计学意义(P<0.05)。结论舌下含服尘螨疫苗治疗变应性鼻炎疗效好,且早期配合药物对症治疗能提高患者的依从性。

Objective To evaluate of the efficacy and safety of sublingual immunotherapy dust mite allergic rhinitis vaccine.Methods Using a simple dust mite sublingual（n= 38）and sublingual vaccine containing dust mites with drug treatment（n=38）were compared,whereas 76 patients allergic to dust mite allergic rhinitis patients were observed in a 6-month clinical stduy.Results In the two groups,the dust mite allergic rhinitis symptoms after treatment than before treatment were significantly improved（P0.05）.The effective rate of the simple sublingual treatment was 63.16% and that of the combined treatment was 86.84%（P0.05）.Conclusion For dust mite sublingual vaccine for allergic rhinitis,the combined therapy was better than the sublingual vaccine.Early symptomatic medical treatment can improve the patient compliance.