摘要
近年来国内外对甘草酸肝损伤的研究证实了甘草酸具有抗病毒、抗感染和调节机体免疫功能、、的作用(glycyrrhizic acid,GL)防治抗氧化应激抑制肝细胞凋亡和促进肝细胞再生。笔者综述了近年来甘草酸在体内外实验动物模型中,抗四氯化碳(CCl4)、D-氨基半乳糖、脂多糖,抗肝纤维化与其他类型的急性肝损伤防治等方面的药理研究进展。
In recent years, the studies of glycyrrhizic acid in the prevention and treatment of liver injury at home and abroad have been confirmed. The glycyrrhizic acid has the effects of anti-virus, anti-inflammation, adjusting immunity, anti-oxidative stress, inhibiting liver cell apoptosis and promoting hepatocyte regeneration. The researches of prevention and treatment of glycyrrhizic acid on animal models in vivo and in vitro such as counteracting carbon tetrachloride（CCl4）, D-galactosamine, lipoplysaccharide, liver fibrosis and other causes leading to acute liver injury have been reviewed.
出处
《抗感染药学》
2010年第4期232-236,共5页
Anti-infection Pharmacy
关键词
甘草酸
肝损伤
抗病毒
肝细胞凋亡
肝细胞再生
glycyrrhizic acid
liver injury
anti-virus
liver cell apoptosis
hepatocyte regeneration
