昆明市铁路职工高尿酸血症及其肾损害的流行病学研究

Kunming Railway Worker High Uric Acid Hematic Disease and Renal Damage Epidemiological Studies

目的:研究昆明市铁路系统职工人群中高尿酸血症(HUA)的发病情况及其与慢性肾脏病(CKD)的关系。方法:在昆明市铁路系统职工中采用分层整群抽样方法,把整个铁路系统职工分为机关管理部门、基层工作部门和后勤服务部门三层,分别从每层随机选出1/3的部门的所有人员共1204人,进行问卷调查、体格检查和血尿检测。结果:在资料完整的1103人中,经过人口年龄、性别构成比校正后,HUA的患病率为18.32%;CKD的患病率为14.61%。其中,HUA组CKD的患病率为22.46%,明显高于血尿酸正常组;HUA组蛋白尿的发病率为15.17%,明显高于血尿酸正常组;HUA组GFR下降的患病率为4.83%,明显高于血尿酸正常组;而两组血尿的发病率没有明显区别。结论:昆明市铁路系统职工人群中,HUA的患病率为18.32%,CKD的患病率为14.61%。HUA组CKD的患病率明显高于血尿酸正常组,HUA可能为CKD的独立危险因素。

Objective：To investigate the prevalence of hyperuricemia and its relationship with chronic kidney disease in Kunming railway workers.Methods：using a stratified cluster sampling,1 204 residents from three floors of Kunming Railway Workers （departments of management,grass-roots works and logistics services departments,one-third on each floor） were randomly selected to be interviewed and tested for the damage indicators.Results：Eligible data of 1103 subjects were enrolled in the study.after the adjustment of age and gender component,the prevalence of hyperuricemia was 18.32%; CKD 14.61%.In people with hyperuricemia,the prevalence of CKD was 22.46%,being significantly higher than in those with normal blood uric acid.the prevalence of proteinuria,in people with hyperuricemia was 15.17% and was significantly higher than in those with normal blood uric acid.with hyperuricemia,The prevalence of GFR decline was 4.83%,being significantly higher than in those with normal blood uric acid.there were no significant difference in the prevalence of hematuria in both.Conclusion：The prevalence of hyperuricemia was 18.32% and the prevalence of CKD was 14.61% in Kunming railway workers population.People with hyperuricemia have a higher prevalence of CKD than those with normal serum uric acid.hyperuricemia may be an independent risk factor for CKD.