中药五灵脂的化学成分研究

Chemical Constituents of Trogopterus xanthipes

从中药五灵脂(Trogopterus xanthipes)的丙酮提取物中分离得到3个化合物,其结构经波谱鉴定为3-hy-droxy-(3-hydroxyphenyl)-benzenepropanol(1)、trans-2-(3,5-dihydroxybenzyl)-3-(3-hydroxybenzyl)-γ-butyrolactone(2)和tocopherylquinone(3)。其中化合物1为一个新的降木脂素类成分,化合物2为首次从自然界获得的新化合物,化合物3为首次从该中药中分离得到。化合物3在白血病肿瘤细胞株活性测定实验中显示中等的细胞毒活性,其IC50为20.7μM。

Three compounds were isolated from the acetone extract of Chinese traditional medicine of Trogopterus xanthipes.They were identified as 3-hydroxy-（3-hydroxyphenyl）-benzenepropanol（1）,trans-2-（3,5-dihydroxybenzyl）-3-（3-hydroxybenzyl）-γ-butyrolactone（2）,and tocopherylquinone（3） using spectroscopic methods.Compound 1 is a new norlignan.Compound 2 was firstly isolated from natural origin,and 3 was isolated from this species for the first time.Compound 3 showed moderate cytotoxic acticity against U937 human cell line with IC50 value of 20.7 μM.