电针治疗周围神经损伤的修复机制

Mechanisms of electroacupuncture therapy for peripheral nerve injury

背景:多年来临床及实验研究表明,电针治疗对周围神经损伤修复有着肯定的效果,其相关机制也一直是针灸研究者关注的热点之一。目的:总结电针治疗周围神经损伤的研究现状及其可能机制,以期更深入地探讨电针治疗周围神经损伤的机制,促进针灸临床疗效的提高。方法:由第一作者应用计算机检索中国知识资源总库和Ovid数据库,检索词分别为"电针;周围神经"和"electro acupuncture;peripheral nerve regeneration",语言分别设定为中文和英文。纳入所述内容与电针治疗对周围神经损伤修复的疗效及作用机制相关的文献,排除相关性较低、重复研究以及较陈旧的文献。结果与结论:计算机初检得到138篇文献,阅读标题和摘要进行筛选,共纳入27篇符合标准的文献。经分析得出以下结论:电针是治疗周围神经损伤的有效方法。其治疗机制可通过生物电场作用、改善运动终板内的营养物质含量和结构、促进神经生长相关蛋白表达增多、促进神经营养因子3及其受体表达增多、增强神经生长因子-信使核糖核酸的表达以及促进许旺细胞的增殖等方面来促进周围神经损伤的修复。

BACKGROUND：Previous clinical and experimental studies indicate that electroacupuncture is an effective therapy on repairing injured peripheral nerve,and its repair mechanism is always a hot focus of the studies on acupuncture.OBJECTIVE：To review the progress and the mechanisms of injured peripheral nerve repairing by electroacupuncture therapy,to explore more deeply on the mechanisms of injured peripheral nerve repairing by electro acupuncture therapy,and to improve the curative effect of acupuncture.METHODS：Papers related to therapy for peripheral nerve injury in CNKI and in Ovid database were searched with Keywords of ＂electroacupuncture;peripheral nerve regeneration＂ both in Chinese and English.The articles regarding electro acupuncture,or peripheral nerve regeneration were selected,and the duplicated study or Meta analysis was excluded.RESULTS AND CONCLUSION：Totally 138 literatures were collected,and 113 of them were excluded,thus,27 documents were included.Analysis results showed that electro acupuncture is an effective treatment strategy on repairing injured peripheral nerve.The mechanisms are that the action of bioelectricity,the improvement of nutrient contents and structures in motor endplate,the promotion on increasing of nerve growth associated protein,the promotion on increasing of neurotrophy factor 3 and its acceptor,enhanced expression of neurotrophy factor-RNA,and the promotion on Schwann cell generation.