摘要
目的探讨AEG-1在宫颈癌中的表达情况及其与临床病理特征的关系。方法应用免疫组织化学sP法检测21例正常宫颈组织、36例宫颈鳞状细胞癌组织、18例宫颈腺癌组织和30例宫颈上皮内瘤样病变(CIN)组织中AEG-1蛋白的表达,并分析其与临床病理特征及肿瘤恶性程度间的关系。结果AEG-1蛋白在宫颈鳞癌和宫颈腺癌组织中的阳性表达率分别为69.4%和72.2%,高于其在CIN组织和正常宫颈组织中40.0%、0.0%的表达率,其差异具有统计学意义(P〈0.05)。AEG-1的阳性表达与宫颈癌临床分期、淋巴结转移、病灶大小、脉管浸润及肌层浸润密切相关,有统计学意义(P〈0.05);与宫颈癌的组织学分级、组织学分型及年龄无关(P〉0.05)。结论AEG-1过表达与宫颈癌的发生、发展密切相关,AEG-1的过表达可作为预测宫颈癌恶性程度和不良预后的重要指标。
Objective To explore the expression of AEG - 1 in cervical cancer and the relationship with clinicopathological characteristics. Methods The expression of AEG - 1 was detected by immunohistochemisty S -P method in 21 cases of normal cervical specimens ,36 cases of squamous carcinoma of the cervix, 18 cases of adenocarcinoma of the uterine cervix and 30 cases of C|N. The correlation between immunohistochemical results and clinicopathological characteristics were analyzed by SPSS software. Results The positive expression ratios of AEG - 1 in squamous carcinoma of the cervix and adenocarcinoma of the uterine cervix were 69.4% and 72.2% respectively, which were significantly higher than those in CIN(40% )and normal cervical tissue(0% ). There was a strong correlation between AEG- 1 expression and clinical staging,lymph nodes metastasis, tumor sizes, vessel invasion and lamina muscularis invasion( P 〈 0.05 ) , whereas it was not associated with histological differentiation, histological classification and age ( P 〉 0.05 ). Conclusion The upregulation of AEG - 1 may play an important role in the development and pothogensis of cervical cancer. The overexpression of AEG - 1 could be a valuable marker to predict the malignant degree and poor prognosis of cervical cancer.
出处
《实用肿瘤学杂志》
CAS
2010年第6期529-532,576,共5页
Practical Oncology Journal