黄芩苷脂溶性栓剂的制备与质量控制

Preparation and Quality Control of Baicalin Suppository

目的:制备黄芩苷脂溶性栓剂,考察栓剂的质量和体外释放。方法:制备黄芩苷脂溶性栓剂,按照药典方法检测栓剂质量,采用高效液相色谱法测定栓剂中黄芩苷的含量,紫外分析方法检测栓剂体外释放液中的黄芩苷,计算累积释药量。结果:栓剂的硬度、融变时限、体外释放的特性均符合《中国药典》的要求。结论:该栓剂的制备方法简单易行,质量控制方法可靠。

Objective：To prepare baicalin suppository and to establish a method for quality control of the suppository.Method：The baicalin suppository was prepared with heating method.The baicalin was determined by HPLC.The vitro release of baicalin suppository was studied.Result：The average recovery of baicalin was 101.4% RSD 0.1%.Conclusion：This preparation method was easy to operate;the quality was stable and controllable.