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抗耐甲氧西林金黄色葡萄球菌的中药筛选 被引量:20

Screening of traditional Chinese medicines against methicillin-resistant Staphylococcus aureu
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摘要 目的以50种常用中药筛选抗耐甲氧西林金葡菌(MRSA)的中药。方法采用K-B纸片扩散法从50种中药初步筛选;通过琼脂平板抑菌法观察所筛选的5种抗MRSA作用最强的中药的MIC;采用微量液体平板棋盘法研究5种中药两两联合应用的抗菌作用。结果抗菌筛选实验中50种中药有35种产生抑菌圈,其中以黄连、黄柏、大黄、银柴胡和石榴皮的抑菌圈直径最大,黄连和黄柏联合应用时抗菌指数(FIC)<0.5。结论所选中药多数具有抗MRSA作用,其中以黄连、黄柏、大黄、银柴胡和石榴皮的作用最强,黄连和黄柏联合应用因协同作用抗菌作用最强,为中药抗MRSA的较好选择。 Purpose To screen traditional Chinese medicines using powerful antibacterial activity against methicillin-resisistant Staphylococcus aureu(MRSA).Methods The Chinese medicines with powerful antibacterial activity against MRSA were selected from 50 traditional Chinese medicines by Kirby-Bauer.The MICs of selected Chinese medicines with powerful antibacterial activity against MRSA were performed by agar disk.Synergetic antibacterial test of each two of the selected 5 Chinese medicines against MRSA were carried out by trace multi-well culture plates.Results 35 Chinese medicines had inhibitory effects on the strain of MRSA with varied extent in 50 Chinese medicines,among which were Coptis chinensis,Cortex Phellodendri,Rhubarb,Radix Stellariae and granatum.Furthermore,FIC index is <0.5 when Coptis chinensis and Cortex Phellodendri were in combined use.Conclusion Most of the selected traditional Chinese medicines have certain inhibitory effect on MRSA,in which Coptis chinensis,Cortex Phellodendri,Rhubarb,Radix Stellariae and granatum have powerful antibacterial activity against MRSA,and the combined use of Coptis chinensis and Cortex Phellodendri has the strongest inhibitory effect on MRSA because of synergistic effect,and it is the better choice in anti-MRSA Chinese medicines.
作者 宓伟 何深一
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2011年第1期44-46,共3页 Chinese Journal of Biochemical Pharmaceutics
关键词 耐甲氧西林金葡菌 最低抑菌浓度 黄连 黄柏 methicillin-resisistant Staphylococcus aureu antibacterial activity minimal inhibitory concentration Coptis chinensis Cortex Phellodendri
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