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bcl-2蛋白在肝细胞肝癌发生过程中的表达及其与肝细胞凋亡变化的关系 被引量:5

BCL2 EXPRESSION IN THE HEPATOCELLULAR CARCINOGENETIC PROCESS AND ITS RELATIONSHIP WITH HEPATIC CELL APOPTOSIS
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摘要 为探讨肝细胞肝癌发生过程中bcl2蛋白的变化规律及与细胞凋亡变化的关系,运用TUNEL法和免疫组化方法检测石蜡保存的肝细胞肝癌组织(hepatocelularcarcinoma,HCC)、肝硬变组织(livercirhosis,LC)和正常肝组织(normalliver,NL)中细胞凋亡发生率和bcl2的表达。结果:从NL、LC到HCC组织,细胞凋亡活性出现增强;bcl2蛋白的表达逐渐下降,LC和HCC组比较,P<0.05。结论:bcl2的表达可能与肝细胞凋亡的抑制有关;在肝癌发生过程中,bcl2表达下降可能是引起肝癌细胞凋亡增加的原因之一。 To elucidate bcl2 protein expression in hepatic carcinogenetic process and its relationship with apoptotic changes. bcl2 protein was evaluated immunohistochemically while apoptosis was approached with terminal deoxynucleotidyl transferase (TdT)mediated dUTP nick end labeling (TUNEL) technique in 8 normal livers (NL), 17 liver cirrhosises (LC) and 77 hepatocellular carcinomas (HCC). The results showed that bcl2 protein was expressed in 3 of 8 NLs(37.5%), 5 of 17 LCs(29.4%) and 7 of 77 HCCs(9.1%) with significant differences between group NL and HCC and between LC and HCC (P<0.05). Apoptosis rates of 1.180.42%, 4.852.78%, 12.892.33% in NL, LC, HCC group respectively were demonstrated with significant differences among them (P<0.01). Compared the bcl2 expression with the apoptosis rate in this hepatocarcinogenetic process, reversed trends were presented. Conclusion: bcl2 expression could be detected in NL, LC and HCC, and its decreasing expression was related to the inhibition attenuation of hepatocell
出处 《中国普外基础与临床杂志》 CAS 1999年第4期193-195,共3页 Chinese Journal of Bases and Clinics In General Surgery
关键词 BCL-2基因 肝癌 细胞凋亡 bcl2 geneHepatocellular carcinomaApoptosisular apoptosis in the process of hepatocarcinogenesis.
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