肾糖颗粒对糖尿病肾病大鼠疗效的实验研究

Effect of Renal Sugar Granules on the Diabetic Nephropathy Rats

目的通过中药肾糖颗粒对糖尿病大鼠的治疗作用,探讨其临床实验效果。方法采用高脂饲料喂养+STZ腹腔注射方法制作糖尿病肾病大鼠模型。分为正常对照组、模型对照组、中药治疗组(肾糖颗粒)、西药治疗组(盐酸贝那普利)、中西药治疗组(肾糖颗粒+盐酸贝那普利),观察各组大鼠治疗前后一般情况,并测定治疗后空腹血糖,24h尿蛋白定量,尿微量白蛋白,α1-微球蛋白、β2-微球蛋白、尿转铁蛋白、尿视黄醇结合蛋白。结果经肾糖颗粒治疗8周后,大鼠一般状况较模型对照组改善较好,体质量增加。空腹血糖,与模型组比较,各治疗组显著降低;24h尿蛋白定量、尿微量白蛋白、α1-微球蛋白、β2-微球蛋白,各治疗组也分别显著低于模型组;尿转铁蛋白、尿视黄醇结合蛋白,各治疗组均分别显著低于模型组。结论肾糖颗粒对糖尿病肾病大鼠有治疗效果,可以改善其肾功能,延缓糖尿病的肾脏损伤。

Objective：To observe the efficacy of renal sugar granules on STZ-induced diabetic nephropathy rats.Methods：The model was induced by feeding with high fat diet and STZ produced by intraperitoneal injection in rats.All rats were randomly divided into 5 groups including the normal control group,the model control group,the Chinese medicine group（Renal sugar granule group）,the western medicine group（Lotensin group） and the Chinese and Western medicine group（Renal sugar granule and Lotensin group）.The general situations of these rats were observed before and after treatmen.After the treatment,some indices were detected including the fasting blood glucose,the 24h urinary protein,the urinary albumin,the α1-microglobulin,the β2-microglobulin,the urinary transferring and the retinol-binding protein.Results：After treatment for 8 weeks with renal sugar granule,the general situations improvements were more obvious than those in the model rats.Compared with the model group,the fasting blood glucose in the treatment groups were significantly lower.24h urine protein,urinary albumin,α1-microglobulin and β2-microglobulin in the treatment groups were also significantly lower than those in the model group.The urinary transferring and the retinol-binding protein in several groups were lower remarkably than those in the model group.Conclusion：Renal sugar granules have a certain therapeutic effect on STZ-induced diabetic nephropathy rats.It can improve the function of kidney and delay the damage of kidney.