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针灸预处理对阿尔茨海默病大鼠学习记忆行为的影响 被引量:7

Influences of Acupuncture and Moxibustion Preconditioning on Learning and Memory of Alzheimer's Disease Rats
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摘要 目的观察针灸预处理对AD大鼠学习记忆行为的影响。方法大鼠随机分为正常组、假手术组、模型组、预艾灸组、预电针组、预电针加灸组,在大鼠双侧海马区注射Aβ25-35,建立AD大鼠模型,通过定位航行实验和空间搜索实验检测针灸预处理对记忆损害的预防和治疗作用。结果模型组大鼠学习记忆能力有明显损害,其平均潜伏期、经过中心区域的比例、平均游过的路径距离与正常组和假手术组有显著差异(P<0.01),而预电针和预艾灸对其有明显的预防和改善作用,其中以预电针加灸的疗效最好。结论针灸预处理对AD大鼠学习记忆行为具有保护作用。 Objective To observe acupuncture and moxibustion preconditioning on learning and memory in the rats model of Alzheimer's disease.Methods Aβ25-35 was injected into the bilateral hippocampal zones of rats to establish the AD model.All the rats were randomly divided into six groups as: normal,sham operation,model,moxibustion precondistioning,electroacupuncture(EA) preconditioning,preconditioning of EA plus moxibustion.Through the place navigation test and probe trial testing to detect preventive and therapeutical effects of acupuncture and moxbustion on memory impairment.Results The model rats' ability of learning and memory were damaged obviously,and the average latency,the ratio of rats crossing the center area,average swimming distance of crossing the path were of significant difference between the normal group and sham group(P0.01).The preconditioning of EA and moxibustion showed obvious effects of improvement and prevention,with the best efficacy observed in acupuncture plus moxibustion preconditioning.Conclusions Preconditioning of acupuncture and moxibustion effectively protects rats on learning and memory.
机构地区 湖北中医药大学
出处 《湖北中医学院学报》 2011年第1期3-5,共3页 Journal of Hubei College of Traditional Chinese Medicine
基金 国家自然科学基金(30772837) 武汉市晨光科技计划(200850731347)
关键词 针灸预处理 AD 定位航行实验 空间搜索实验 Preconditioning of acupuncture and moxibustion Alzheimer's Disease Place navigation test Probe trail testing
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