鲍氏不动杆菌医院感染分布及耐药性监测

Distribution of acinetobacter baumannii infection and surveillance of drug resistance

目的研究鲍氏不动杆菌的感染分布及对常用抗菌药物的敏感性,以指导临床合理用药。方法收集病区感染病例的临床资料,应用VITEK-32的GNI卡对临床标本中分离出的细菌进行鉴定,药敏纸片进行药物敏感试验。结果 320株鲍氏不动杆菌来自痰液标本的最多,占63.75%,其次为尿液和脓液,分别为10.63%和9.06%;感染科室分布分别为呼吸内科占29.38%,ICU占24.06%;鲍氏不动杆菌对β-内酰胺类、喹诺酮类和氨基糖苷类有较高的耐药率,对碳青霉烯类,含酶抑制剂敏感性较高。结论鲍氏不动杆菌在临床的多药耐药呈上升趋势,加强细菌耐药性的监测,提倡合理使用抗菌药物,是预防和控制鲍氏不动杆菌医院感染的有效措施。

OBJECTIVE To investigate the distribution and drug resistance of Acinetobacter baumannii isolates in order to provide guidance for clinical medication. METHODS The clinical data were collected from infected 320 strains, the bacterial identification of A. baumannii isolates was carried out by using GNI of VITEK32. RESULTS Totally 320 A baumannii from sputum specimens of the largest accounted for 63.75%, followed by urine and pus, accounted for 10.630% and 9.06%, respectively. The distribution of infected sections of respiratory department, respectively accounting for 29.38% ,ICU accounted for 24.06 %. The Acinetobacter baumannii were resist to the β-laetamases,fluoroquinolones aminoglycosides antibiotics, the sensitive rates to carbapenem were rather high. CONCLUSION The infection of multi-drug resistant A. baumannii has ascending tendency. It is important to strength monitoring the drug resistance and advocate to use antibiotic drugs reasonably, so that we can prevent and control the prevalence of A. baumannii.