瑞波西汀与氟西汀治疗抑郁症的系统评价

Systematic review of reboxetine versus fluoxetine in the treatment for depression

目的：比较瑞波西汀与氟西汀治疗抑郁症的疗效及不良反应的差异。方法：检索国内关于瑞波西汀与氟西汀对照研究治疗抑郁症的文献，应用系统评价方法对查阅到的9篇进行评估。结果：瑞波西汀与氟西汀的疗效差异无显著性[P〉0．05，OR=1．01，95％CI（0．77～1．32）]，2组药物不良反应的发生率差异无显著性（P〉0．05）。结论：瑞波西汀与氟西汀的疗效治疗抑郁症的疗效和不良反应相似，是一种安全有效的抗抑郁药。

OBJECTIVE To compare the difference in therapeutic effects and side effects between reboxetine and fluoxetine. METHODS A total of 9 paper about control study comparing reboxetine with fluoxetine in treatment of depression retrieved from home were subjected to system evaluation. RESULTS There was no significant difference on clinical efficacy between reboxetine group and fluoxetine group [P〉0. 05 ,OR = 1.0,95%CI（0. 77-1.32）]. There was also no significant difference of adverse events between reboxetine and fluoxetine groups. CONCLUSION Reboxetine is similar to fluoxetine in efficacy and adverse reactions, and it is an effective and safe drug for in the treatment of depression.