摘要
目的:观察盐酸多奈哌齐(阿瑞斯)治疗3种不同类型老年痴呆的临床疗效。方法:对70例老年痴呆患者给予多奈哌齐(阿瑞斯)5mg,1次/日,8周为1个疗程。治疗前、后分别测定简易智能精神状态检查量表(MMSE)及日常生活活动能力量表(ADL)。结果:治疗后MMSE分值:老年性痴呆(AD)组明显提高(P<0.01);血管性痴呆(VD)组无明显变化(P>0.05)。混合性痴呆组有提高(P<0.05)。治疗后ADL分值变化:AD组下降(P<0.05),VD组和混合性痴呆组无明显下降(P>0.05)。结论:盐酸多奈哌齐对AD患者及部分混合性痴呆患者认知及记忆功能改善有一定疗效,对VD患者无明显疗效。
Objective：To observe the efficacy of donepezil in the treatment of three different kinds of old de2mentia. Methods ：70 patients were treated with Donepezil, 5mg q. d. for 8 weeks. The efficacy was judgedby MMSE and ADL. Results： After the treatment of Donepezil, AD patients was hightened by MMSE scorethan before （P 〈 0. 01 ）. But the score of VD patients had no obvious change （ P 〉 0. 05 ） , and mixed demen2tia was improved litter （ P 〈 0. 01 ）. However,the ADL score of AD patients was declined（ P 〈 0. 05 ）. Andthere was no significant difference between before and after treating VD and mixed dementia patients withDonepezil （ P 〉 0. 05 ）. Conclusion： Donepezil is effective in treating the cognition of AD andsome of the mixed dementia, but it has little effect on VD.
