新一代大环内酯类抗生素地红霉素

Dirithromycin, A New generation Macrolide Antibiotic

新一代大环内酯类抗生素地红霉素是红霉素的衍生物。其抗菌活性与红霉素类似，具有比红霉素优异的药代动力学特性，对酸稳定，临床上对各种感染性疾病均有满意的疗效。本文综述了地红霉素的合成工艺、体内外抗菌作用、药代动力学特性和临床应用。

Dirithromycin is a new generation macrolide antibiotic which derives from erythromycin. The antibacterial activity of dirithromycin is similar to that of erythromycin.Dirthromycin showed the improved pharmacokinetics compared to erythromycin and was stable to acids. In clinical trail, dirithromycin showed excellent effects for the treatment of various infections. This article reports four aspects about dirithromycin:synthesis technology, antibacterial activities,pharmacokinetics and clinical effects.