宫颈病变组织Survivin的表达及其临床意义

Expression of Survivin protein in tissues of cervical squamous cell carcinomas and its clinical significance

目的:探讨Survivin在宫颈鳞状上皮细胞癌(CSCC)和宫颈上皮内瘤变(CIN)组织中的阳性表达及相关性。方法:用免疫组织化学(IHC)SP法检测92例CSCC及癌旁正常宫颈组织和40例CIN组织中Survivin的蛋白表达情况,并对数据进行统计分析。结果:CSCC组中Survivin阳性表达率为78.26%(72/92),CINⅠ、CINⅡ和CINⅢ组分别为26.67%(4/15)、64.28%(9/14)和72.72%(8/11);正常宫颈鳞状上皮组织Sur-vivin阳性表达率为2.17%(2/92)。宫颈鳞癌组、CINⅡ、CINⅢ组Survivin的阳性表达明显高于CINⅠ组及正常宫颈组织,P<0.01;CINⅠ与CINⅡ、CINⅢ组之间Sur-vivin表达差异有统计学意义,P<0.05;Sur-vivin的表达在各组均与年龄无关。结论:Survivin的阳性表达与宫颈癌的进展、组织学分级和临床分期有关,而与年龄无关。宫颈癌临床分期越晚、细胞分化程度越低,Sur-vivin的阳性表达率越高。

OBJECTIVE：To study the protein expression of Survivin in the tissues of cervical disease,and the changes and correlation between cervical squamous cell carcinomas（CSCC） and cervical intraepithelial neoplasia（CIN）.METHODS： The protein expression of Survivin was examined by SP immunohistochemical stain（IHC） method in 92 tumors of CSCC,corresponding normal tissues and 40 CIN tissues,and the results were analyzed.RESULTS：The positive expression rates were 78.26%（72/92） in CSCC,and 26.67%（4/15）,64.28%（9/14）,72.72%（8/11） respectively in the CINⅠ,CINⅡ,CINⅢ groups.The positive expression rate was 2.17%（2/92） in corresponding normal tissues.The protein expressions of Survivin in CSCC,CINⅡ and CINⅢ were significantly higher than those in the CINⅠ group and the corresponding normal tissues（P0.01）.The protein expression of CINⅠ was significantly lower than those in the CINⅡ and CINⅢ groups（P0.05）.The Survivin expression was not correlated with age.CONCLUSION： The protein expression of Survivin is correlated with the progression of cervical cancer,histological graduation and clinical stages,but has no correlation with age.