妊娠期高血压综合征患者甲胎蛋白水平及其对围生儿预后的影响

The level of alpha-fetoprotein in patient with pregnancy-induced hypertension syndrome and the effect of its to prognosis of perinatal infant

目的探讨妊娠期高血压综合征(PIH)患者血清甲胎蛋白(AFP)水平及其对围生儿预后的影响,为临床预测PIH及围生儿预后提供依据。方法采用放射免疫法测定118例PIH孕妇(PIH组)和160例正常孕妇(对照组)的血清AFP水平,并随访至分娩,分析PIH患者血清AFP水平与妊娠结局及围生儿预后的相关性。结果 PIH组血清AFP水平为(209.88±34.18)μg/L明显高于对照组的(177.58±32.67)μg/L,差异有统计学意义(P<0.05);重度亚组血清AFP水平高于轻度、中度亚组孕妇及对照组,差异均有统计学意义(P<0.05)。PIH组中AFP水平≥250μg/L足月小样儿发生率、孕妇新生儿出生1min Apgar评分≤7分者百分率及围生儿病死率均高于<250μg/L者,差异均有统计学意义(P<0.05)。结论孕妇血清AFP水平可作为判断PIH病情轻重及判断围生儿预后的指标。

Objective To investigate the level of serum alpha-fetoprotein（AFP） in patients with pregnancy-induced hypertension syndrome（PIH） and the effect of its to prognosis of perinatal infant.Methods By radioimmunoassay maternal,measured the level of serum AFP of 118 cases patients with PIH（PIH group） and 160 cases normal pregnant women（control group）,followed up to delivery,and analyzed the relativity of AFP level in patients with PIH to pregnancy outcome and prognosis of perinatal infant.Results The serum AFP level of PIH group[（209.88 ± 34.18） μg/L] was significantly higher than that of control group[（177.58 ± 32.67） μg/L],the difference was statistically significant（P 0.05） ;The serum AFP level of severe subgroup was higher than that of mild,moderate subgroup,the difference were statistically significant（P 0.05）.The incidence of small-for-gestational-age,percentage of newborns of 1min Apgar score≤7,and perinatal mortality of patients of the AFP level≥250μg/L were higher than those of patients of the AFP level 250μg/L,the difference were statistically significant（P0.05）.Conclusion The serum AFP level can be used to determine the severity of PIH,and to determine the prognosis of perinatal infant.