运动性软骨损伤与组织工程化软骨及生物支架材料的修复

Exercise-induced cartilage damage repair with tissue engineered cartilage and biological scaffold materials

背景:篮球运动中造成软骨损伤较为常见。随着组织工程和生物材料的应用发展,利用软骨组织工程化或支架材料修复已成为趋势。目的:对篮球运动中造成软骨损伤的因素进行探讨,重点对组织工程支架材料修复过程中关注的3个要素的研究和运用情况进行概括。方法:由第一作者检索2005-01/2010-10PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及万方数据库(http://www.wanfangdata.com.cn)。英文检索词为"crtilage,damage,treatment,biological materials",中文检索词为"组织工程;软骨损伤;修复;生物材料;种子细胞"。检索文献量总计120篇,选择文章内容与软骨治疗方法、材料学特点、生物相容性、材料改性、表面修饰及其应用效果相关等方面的文献,排除陈旧及重复实验文章,同一领域文献则选择近期发表或发表在权威杂志的文章,最终纳入30篇符合标准的文献。结果与结论:种子细胞、支架材料和体外培养环境,构成了软骨组织工程学注重的3个要素,3者组成了一个相互促进相互制约的整体,以组织工程技术修复软骨损伤时应注重到3者间的恰当选择和配置。

BACKGROUND：The cartilage damage is common in basketball exercise.With the application and development of tissue engineering and biological materials,cartilage tissue engineering or scaffold repair has become a trend.OBJECTIVE：To investigate the factors associated with cartilage damage in basketball exercise,with emphasis on the application of three elements concerned in the repair process of tissue engineering scaffold materials.METHODS：An online search of PubMed database（http：//www.ncbi.nlm.nih.gov/PubMed） and Wanfang database（http：//www.wanfangdata.com.cn） between January 2005 and October 2010 was performed by the first author.English key words are ＂cartilage,damage,treatment,biological materials＂,Chinese key words are ＂tissue engineering;cartilage injury;repair;biological materials;seed cells＂.A total of 120 literatures were screened out,articles about cartilage treatment,materials science characteristics,biocompatibility,material modification,surface modification and its application were selected,old and repeated experiments were excluded.Those recently published or published in the authority magazine were preferred in the same area,and ultimately 30 literatures in accordance with the include criteria were involved.RESULTS AND CONCLUSION：The seed cells,scaffolds and in vitro culture environment are three elements for of cartilage tissue engineering,and compose a body of mutual promotion and mutual restraint.The appropriate selection and collocation of these 3 elements should be taken into consideration of repairing cartilage injury with tissue engineering technology.