NF-κB信号通路与炎症性肠病

NF-κB signaling pathway and inflammatory bowel disease

炎症是多种细胞及细胞因子参与的机体防御性反应,但严重或长期的炎症则会造成机体损伤.炎症性肠病(inflammatory bowel disease,IBD)是一组以慢性、周期性炎症为特征的胃肠道疾病,长期、反复的胃肠道炎症不仅影响患者生活质量,而且增加了肠道纤维化及癌变的风险,而核因子Kappa B(nuclear factor-kappa B,NF-κB)与炎症反应关系非常密切.本文就NF-κB信号通路与IBD的联系作一简要概述.

Inflammation is a defensive reaction involving a variety of cells and cytokines.However,serious or long-term inflammation may cause impairment of organisms.Inflammatory bowel disease（IBD） is a group of gastrointestinal diseases characterized by chronic and periodic inflammation.Long-term,repeated gastrointestinal inflammation not only influences the quality of life of patients but also increases the risk of fibrosis and carcinoma in the intestinal tract.It has been demonstrated that nuclear factor-kappaB（NFκB） signaling has a close relationship with inflammation.The aim of this paper is to discuss the relationship between NF-κB signaling pathway and IBD.