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还原型谷胱甘肽对慢性阻塞性肺疾病急性加重期患者氧化应激的影响 被引量:18

The impact of reduced Glutathione in oxidative stress of acute exacerbation in patients with chronic obstructive pulmonary disease
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摘要 目的研究还原型谷胱甘肽对慢性阻塞性肺疾病(COPD)急性加重期患者氧化与抗氧化能力的影响。方法检测20例健康成年人全血丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)含量,并与72例COPD急性加重期患者治疗前的上述指标进行对应比较,发现COPD急性加重期的全血GSH-PX的活性比健康组低,而MDA的含量比健康组高。进而将72例COPD急性加重期患者,随机分成2组,试验组在给予常规治疗的同时合并给予还原型谷胱甘肽1.2g/d稀释后静脉滴注,疗程2W,对照组只给予常规治疗。2W后复测上述指标,发现治疗后全血GSH-PX的活性升高,MDA含量降低,而对照组则无显著变化。结果 (1)COPD急性加重期的全血GSH-PX的活性比健康组低,而MDA的含量比健康组高。(2)还原型谷胱甘肽试验组治疗前后比较,治疗后全血GSH-PX的活性升高,MDA含量降低,存在显著差异(P<0.05),而对照组则无显著变化。结论 COPD急性加重期患者机体的抗氧化能力降低,还原型谷胱甘肽可通过提高机体的抗氧化能力,消除氧自由基和脂质过氧化物,减轻COPD急性加重期患者氧化应激程度,对COPD患者有一定辅助治疗价值。 Objective To study effects of reduced glutathione in oxidative and antioxidant of patients with acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods Detect malondialdehyde (MDA), glutathione peroxidase (GSH-PX) lev els of whole blood from 20 healthy adults and 72 patients with acute exacerbations of COPD respectively. The indexes between 20 healthy adults and 72 pantients with acute exacerbations of COPD before treatment were compared. We found that GSH PX activity of whole blood in COPD acute exacerbation patients was lower than in healthy group, while the MDA levels were higher in the COPD group. Further 72 cases of acute exacerbation of COPD were randomly divided into two groups,experimental group were giv en conventional treatment and glutathione 1.2g / d diluted intravenous drip for 2 weeks. The control group only received conventional treatment. After 2 weeks,above parameters were measured to compare the changes before and after treatment in each group. Results (1) COPD with acute exacerbation of the whole blood GSH-PX activity was lower than in healthy group,while plasma MDA levels were higher than the healthy group. (2)Reduced glutathione before and after the treatment group after treatment, whole blood GSH-PX activity increased but plasma MDA was reduced, there are significant differences (P〈0. 05), while no signifi cant changes happened in the control group. Conclusion COPD with acute exacerbation of chronic lower antioxidant capacity, re duced glutathione can improve the body's antioxidant capacity, eliminate oxygen radical and lipid peroxides in patients with acute exacerbation of COPD and reduce oxidative stress levels, for adjuvant therapy in patients with COPD, It has a certain value.
出处 《国际检验医学杂志》 CAS 2011年第5期565-566,共2页 International Journal of Laboratory Medicine
关键词 氧化应激 还原型谷胱甘肽 慢性阻塞性肺疾病 Oxidative stress Glutathione Chronic obstructive pulmonary disease
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