摘要
目的:观察黄连解毒汤对改善阿尔茨海默病(AD)小鼠学习记忆能力的作用。方法:3月龄APP/PS1双转基因AD小鼠60只随机分为0.5%羧甲基纤维素钠(CMC)组(等体积0.5%CMC灌胃)、安理申组(3 mg/kg安理申灌胃)、黄连解毒汤大剂量组(865 mg/kg黄连解毒汤灌胃)、黄连解毒汤中剂量组(433 mg/kg黄连解毒汤灌胃)、黄连解毒汤小剂量组(216 mg/kg黄连解毒汤灌胃),各12只,各组给药1次/d,连续给药3个月。于6月龄时行Morris水迷宫实验,检测并比较各组小鼠定位航行逃避潜伏期及平均游泳距离。结果:与CMC组比较,安理申组、黄连解毒汤大、中剂量组第2天~第5天逃避潜伏期明显缩短(P〈0.05),4 d的平均游泳距离缩短(P〈0.05);黄连解毒汤小剂量组逃避潜伏期及4 d的平均游泳距离缩短差异无统计学意义。结论:一定剂量黄连解毒汤对AD小鼠学习记忆能力有明显的改善作用。
Objective: To observe the effects of huang lian jie du decoction(HLJDD) on learning and memory of Alzheimer's disease(AD) mice.Methods: Sixty AD mice were randomly divided into groups CMC,aricept,high dose HLJDD,middle dose HLJDD and low dose HLJDD(each group involved 12 mice).Mice were intragastrically treated with 0.5%CMC,3 mg/kg aricep,865 mg/kg HLJDD,433 mg/kg HLJDD and 216 mg/kg HLJDD respectively once a day for consecutive 180 days.Morris water maze test was applied to measure the learning and memory ability.Results: The escape latency and the average swim path of the mice in aricept,high dose HLJDD,and middle dose HLJDD groups but not in low dose HLJDD group were significantly shorter than that in CMC group(P0.05).Conclusion: HLJDD improves learning and memory ability in AD mice.
出处
《神经损伤与功能重建》
2011年第2期99-102,共4页
Neural Injury and Functional Reconstruction
基金
湖北省自然科学基金资助项目(No.2007ABA060)
关键词
黄连解毒汤
阿尔茨海默病
学习
定位航行
huang lian jie du decoction
Alzheimer's disease
learning
memory