他汀类药物在骨质疏松症方面的研究新进展

New research progress in effects of statins on osteoporosis

他汀类药物(statins)具有调脂,抗炎,抗氧化,抗血栓等作用,现已广泛用于临床治疗和预防心血管疾病的发生,但是近年来研究发现表明他汀类药物还有除调脂以外的作用,尤其在骨质疏松方面的研究得到了学者的重视。众多研究表明他汀类药物具有促进骨生成和抑制骨吸收的双重作用,还具有改善骨的生物力学状况、增加骨密度、降低骨折发生率等作用,而他汀类药物的给药方式和剂量已成为最新的研究重点,这为临床上治疗骨质疏松疾病提供了新的方向。本文就他汀类药物在骨质疏松方面的研究进展作一综述。

Statins, having lipid regulation, anti-inflammatory, antioxidant, and anti-thrombosis functions, have been widely used in clinic for the treatment and prevention of cardiovascular diseases. Nevertheless, recent studies demonstrate that statins show new actions besides their lipid regulation function, especially in the aspect of osteoporosis study which attracts attention by many scholars. Studies show that statins exert double effect by promoting bone formation and by inhibiting bone absorption. In addition, statins can improve the biomechanics of bones, increase bone mineral density, and reduce fracture rate. The drug administration method and dosage have been new focus of research, which also provide a new direction for the treatment of osteoporosis. This paper reviews the current research progress of statins in the aspect of osteoporosis.