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细胞色素P450:肿瘤研究中的新热点 被引量：3

CYP450:a New Hot-spot in Tumor Research
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摘要 细胞色素P450(CYP450)是体内重要的Ⅰ相代谢酶,与许多前致癌物和致癌物的活化有关。CYP450是目前肿瘤研究中新的热点之一。深入研究CYP450在肿瘤发生、发展过程中的作用机制及基因多态性与肿瘤易感性的关系,对肿瘤防治有积极作用。现就近年来CYP450在肿瘤领域的研究进展进行综述。 CytochromeP450（CYP450）is an important phase Ⅰmetabolizing enzyme responsible for the metabolism of numerous of precarcinogen and carcinogen.CYP450 is a hot pan Study on the mechanism of CYP450 contributing to the development of cancer play a positive part in the prevention,diagnosis and treatment of cancer.This article reviewed the research progress of CYP450 in the field of tumor according to the lately researches.
作者 黄聪 黄毅 王凯 石欣
机构地区 东南大学附属中大医院普外科
出处 《现代生物医学进展》 CAS 2011年第8期1591-1593,共3页 Progress in Modern Biomedicine
关键词 细胞色素P450 肿瘤 CYP450 Tumor
分类号 R730.231 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1Jounaidi Y, Waxrnan DJ. Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy [J]. Cancer Res, 2004, 64(1): 292-303.
  • 2王国萍,许敏,张鹏,顾春英,曹广文.细胞色素P4501A1基因多态与肾癌遗传易感性的关系[J].第二军医大学学报,2008,29(8):971-974. 被引量：4
  • 3Sissung TM, Price DK, Sparreboom A,et al. Pharmacogenetics and regulation of human cytochrome P450 1B 1: implications in hormon- e-mediated tumor metabolism and a novel target for therapeutic intervention [J]. Mol Cancer Res, 2006, 4(3): 135-150.
  • 4Letmg YK, Lau KM, Mobley J, et al. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alterna- tive subeellular enzyme compartmentation may contribute to carcinog- enesis [J]. Cancer Res, 2005,65(9):3726-3734.
  • 5Hart EH, Kim HG, Hwang YP, et al. Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells [J]. Toxicol Sci, 2010,114(2): 204-216.
  • 6Maecker B, Sherr DH, Vonderheide RH, et al. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells [J]. Blood, 2003, 10(9): 3287-3294.
  • 7Shi X, Zhou S, Wang Z, Zhou Z, Wang Z. CYP1A1 and GSTM1 pol- ymorphisms and lung cancer risk in Chinese populations: a meta-ana- lysis [J]. Lung Cancer, 2008,59(2): 155-163.
  • 8Sabitha K, Reddy MV, Jamil K. Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer [J]. Cancer Epidemiol, 2010, 34(5): 587-592.

二级参考文献11

  • 1吴清敏,刘巧红,滕云,沈凌汛,王慧,陈燕,杨真荣.外周血DNA提取方法的比较[J].中华检验医学杂志,2004,27(7):445-446. 被引量：25
  • 2Longuemau x S. Delomenie C, Gallou C, Mejean A, Vincent-Viry M,Bouvier R, et al. Candidate genetic modifiers of individual susceptibility to renal cell carcinoma:a study of polymorphic human xenobiotic metabolizing enzymes[J]. Cancer Res, 1999,59 :2903-2908.
  • 3Aktas D, Hascicek M, Sozen S, Ozen H, Tuncbilek E. CYP1A1 and GSTM1 polymorphic genotypes in patients with prostate cancer in a Turkish population [J]. Cancer Genet Cytogenet, 2004,154: 81-85.
  • 4Yang J,Qian L X,Wu H F,Xu Z Q,Sui Y G,Wang X R,et al. Genetic polymorphisms in the cytochrome P450 1A1 and 2E1 genes, smoking, drinking and prostate cancer susceptibility: a case-control study in a Han nationality population in Southern China[J]. Int J Urol,2006,13:773-780.
  • 5Gra O A,Glotov A S, Nikitin E A,Glotov O S, Kuznetsova V E,Chudinov A V,et al. Polymorphisms in xenobiotic-metabolizing genes and the risk of chronic lymphocytic leukemia and non-Hodgkin's lymphoma in adult Russian patients[J]. Am J Hematol, 2008,83 : 279-287.
  • 6Yeh C C,Sung F C,Tang R,Chang-Chieh C R,Hsieh L L. Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan[J]. J Biomed Sci ,2007,14 : 183-193.
  • 7McGrath M,Hankinson S E,De Vivo I. Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States)[J]. Cancer Causes Control, 2007,18:1123-1130.
  • 8Leichsenring A, Losi-Guembarovski R, Maciel M E, Losi-Guembarovski A,Oliveira B W,Ramos G,et al. CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study[J]. Braz J Med Biol Res,2006,39 : 1569-]574.
  • 9Jemal A, Murray T, Ward E, Samuels A, Tiwari R C,Ghafoor A,ct al. Cancer statistics[J]. CA Cancer J Clin,2005,55 : 10-30.
  • 10Cascorbi l,Brockmoller J, Roots I. A C4887A polymorphism in exon 7 of human CYP1A1 :population frequency, mutation linkages. and lung cancer susceptibility[J]. Cancer Res, 1996,56:4965-4969.

共引文献3

同被引文献33

  • 1卢慧,杨磊.细胞色素P4501 A1基因多态性与肿瘤的易感性研究[J].农垦医学,2006,28(6):458-461. 被引量：2
  • 2周小华,韩晓.AhR途径,CYP1A1、CYP1B1,雌激素代谢及作用过程中的调节[J].医学分子生物学杂志,2005,2(3):236-239. 被引量：8
  • 3Forouzanfar MH,Foreman KJ,Delossantos AM,et al.Breast and cervical cancer in 187 countries between 1980 and 2010:a systematic analysis[J].Lancet,2011,378(9801):1461-1484.
  • 4Schiffman M,Castle PE,Jeronimo J,et al.Human papillomavirvs and cervical cancer[J].Lancet,2007,370(9590):890-907.
  • 5Huang M,Chen Q,Xiao J,et al.CYP1A1 Ile462Val is a risk factor for ovarian cancer development[J].Cytokine,2012,58(1):73-78.
  • 6Wang JJ,Zheng Y,Sun L,et al.CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer:a metaanalysis based on32studies[J].Eur J Cancer Prev,2011,20(6):445-452.
  • 7Ahn T,Yun CH.Molecular mechanisms regulating the mitochondrial targeting of microsomal cytochrome P450 enzymes[J].Curr Drug Metab,2010,11(10):830-839.
  • 8Wienkers LC,Heath TG.Predicting in vivo drug interactions from in vitro drug discovery data[J].Nat Rev Drug Discov,2005,4(10):825-33.
  • 9Sissung TM,Price DK,Sparreboom A,et al.Pharmacogenetics and regulation of human cytochrome P450 1 BI:implications in hormone mediated tumor metabolism and a novel target for therapeutic intervention[J].Mol Cancer Res,2006,4(3):135-150.
  • 10Oyama T,Sugio K,Isse T,et al.Expression of cytochrome P450 in non-small cell lung cancer[J].Front Biosci,2008(13):5787-5793.

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现代生物医学进展
2011年 第8期

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