丝裂霉素C提高人工鼻泪管治疗慢性泪囊炎疗效的意义

Influence of mitomycin C in artificial nasolacrimal stent placement to treat chronic dacryocystitis

目的探讨丝裂霉素C（MMC）对提高人工鼻泪管植入术治疗慢性泪囊炎疗效的意义。方法89例（98眼）慢性泪囊炎分为治疗组和对照组。对照组采用人工鼻泪管植入术，而治疗组在人工鼻泪管植入术中及术后7d使用0．02％MMC0．5mL注入泪道。结果术后随访10～12个月，治疗组36眼中有35IliON道冲洗通畅，对照组62眼中有53眼泪道冲洗通畅，差异有统计学意义（P=0．004）。结论在人工鼻泪管植入术中、术后应用MMC是一种能提高远期疗效的安全、有效的辅助措施。

Objective To explore the influence of Mitomycin C （MMC） in artificial nasolacrimal stent placement to treat chronic dacryoeystitis. Methods 89 cases （98 eyes） of chronic daeryocystitis were divided into Mitomycin C group and control group. In the former, 0.5 mL of MMC （0.02%） was injected into the lacrimal duct during the operation and postoperation, and the latter with no MMC. Results All ca- ses were followed-up for 10 - 12 months in the postoperation. Lacrimal drainage systems were patent in 35/ 36 eyes in MMC group, and 53/62 eyes in control group. There was a statistically significant difference be tween MMC group and control group （ P = 0.004, Fisher＇ s Exact Test）. Conclusion MMC in artificial na solacrimal stent placement postoperatively seems a safe and effective adjuvant procedure and can maintain higher long term success rate.