奥曲肽治疗肝硬化上消化道出血的临床观察

Octreotide Treatment of Liver Cirrhosis with Upper Gastrointestinal Hemorrhage

目的探讨奥曲肽治疗肝硬化上消化道出血的疗效。方法入选的肝硬化上消化道出血患者均为我院2008年1月～2010年1月住院患者,根据治疗方法不同随机分为观察组(奥曲肽)和对照组(基础治疗)各30例,比较两组的临床疗效及止血效果。结果观察组的疗效明显优于对照组,止血时间明显短于对照组,48h再出血率明显低于对照组,且并发症的发生率低于对照组,差异有统计学意义(P<0.05)。结论奥曲肽治疗肝硬化上消化道出血疗效确切,并发症少,是理想的治疗药物之一,适于临床广泛推广和应用。

Objective To investigate the octreotide treatment of liver cirrhosis with upper gastrointestinal hemorrhage. Methods Selected patients with upper gastrointestinal bleeding in liver cirrhosis in our hospital in January 2008 to January 2010 hospitalized patients , according to the different treatment methods were randomly divided into two groups （ the octreotide group ） and the control group （ basic treatment ） of the 30 cases in each, two groups were compared the clinical efficacy and hemostatic effects. Results The octreotide group significantly better than the control group, bleeding time was significantly shorter than the control group, 48h rebleeding rate was significantly lower than the control group, and the complication rate is lower than the control group, statistical analysis, shows significance difference （ P 〈 0.05 ） . Conclusion Octreotide treatment of liver cirrhosis with upper gastrointestinal bleeding is effective, fewer complications, is one of the ideal treatment, suitable for clinical and applied widely.