卡前列素氨丁三醇防治高危妊娠产后出血的临床疗效

Prevention of postpartum hemorrhage by hemabate in high risk pregnant women

目的观察卡前列素氨丁三醇(欣母沛)防治宫缩乏力性产后出血的临床疗效。方法选择98例有宫缩乏力性产后出血高危因素的产妇,随机分为治疗组和对照组。治疗组49例胎儿娩出后予缩宫素20 U静脉滴注+卡前列素氨丁三醇250μg宫肌注射;对照组49例胎儿娩出后予缩宫素20 U静脉滴注+缩宫素20 U宫肌注射。比较2组第三产程时间、产后2 h及24 h出血量、产后出血发生率、产后24 h血红蛋白下降值。结果治疗组第三产程时间(3.15±1.35)min,对照组(5.32±1.78)min(P<0.001);治疗组产后2 h出血量(326.6±186.2)mL、产后24 h出血量(389.6±182.4)mL、产后24 h血红蛋白下降值(11.52±3.23)g.L-1,均低于对照组(468.5±193.4)mL、(548.2±226.6)mL、(16.35±4.60)g.L-1,差异均有统计学意义(P<0.001);治疗组产后出血发生率明显低于对照组(P<0.05)。结论卡前列素氨丁三醇预防治疗宫缩乏力性产后出血效果显著,安全性好。

Objective To investigate the effect of hemabate in postpartum hemorrhage caused by uterine atony.Methods A total of 98 women were randomly divided into 2 groups： a treatment group and a control group.The treatment group was given oxytocin 20 U iv.drip and hemmbate 250 μg into the uterine muscle after the delivery of fetus,while for the control group,oxytocin 20 U iv.drip and oxytocin 20 U into the uterine muscle after the delivery of fetus.The amount of bleeding within 2 and 24 h after the delivery,the length of the third stage of labor,and the incidence of postpartum hemorrhage were compared between the 2 group.Results The amount of bleeding within 2 and 24 h after the delivery,haematoglobin decrease 24 h after the delivery in the treatment group were significantly less than those in the control group（P0.001）.The length of the third stage of labor in the treatment group was shorter than that of the control group（P0.001）.The incidence of postpartum hemorrhage in the treatment group was significantly lower than that of the control group（P0.05）.Conclusion Hemabate is more effective and safe in reduction and prevention of atonic postpartum hemorrhage.