脑肠肽Ghrelin对围生期新生儿的影响

Effects of Ghrelin on the perinatal neonates

Ghrelin是一种脑肠肽,在脑-肠轴上对机体的消化功能和能量代谢起着整合作用.近年来研究表明在母乳中能检测到Ghrelin.来自母体的Ghrelin与围生期新生儿自身产生的Ghrelin对其生长发育所具有的特殊生物学效应正日益成为研究热点,如刺激胎儿皮肤细胞的生长及骨骼形成,帮助宫内发育迟缓胎儿出生以后的生长追赶,调节早产儿糖代谢和促进早产儿脂肪合成,促进新生儿免疫系统的发育成熟等.该文就Ghrelin的结构、生理功能及对胎儿、新生儿生长发育和体质量调控的影响作一综述.

Ghrelin is a kind of brain-gut peptides,which integrates the body＇s digestive function and energy metabolism in the brain-gut axis.Recent studies showed that Ghrelin can be detected in breast milk.It is increasingly becoming the focus that Ghrelin from both maternal and perinatal neonates has special biological effects on the growth and development of newborns.such as stimulating the growth of fetal skin cells and the formation of bone,helping the catch-up growth of intrauterine growth restriction fetus after birth, regulating the glucose metabolism and promoting the fat synthesis of premature infants,and improving the maturation of neonatal immune system.This paper reviews the structure and physiological function of Ghrelin.as well as its effects on the neonatal growth and body weight regulation.