摘要
目的了解北京、上海成人胃食管反流病(GERD)和反流性食管炎(RE),在1996年7~9月调查时一年内的患病率及其相关性疾病和危险因素等。方法对两市18~70岁城乡常住人口5000例,进行整群、分层、随机抽样的问卷调查。以反酸、烧心、反食症状程度和频度的积分(Sc,最高18分)作为反流的指标,Sc≥6表明存在症状性反流(GER);再抽取一部分反流阳性病人和对照者用胃镜和24小时pH监测作精查,根据精查的正确率对普查结果校正后测算出患病率。结果(1)共4992例完成了筛查,人群中每日有烧心者占2.5%;Sc≥6者448例占8.97%,男女之比为1∶1.1;精查正确率为64%,据此推测GERD的患病率为5.77%,RE为1.92%。(2)分层分析显示,有反流症状者北京(10.19%)多于上海(7.76%),北京的男性病人、体力劳动者及农村的患病率均高于上海;此外,40岁以上的患病率增多。(3)反流组伴发口咽喉病患、哮喘和支气管炎的频率比非病人人群明显为高。结论调查结果显示,GERD为多发病,但我国南北方的患病率有差别。GERD和RE的比值为3∶1。年龄(OR1.01)、饱食(OR1.99)、油腻食物(OR6.5?
Objective To explore the one yearpoint prevalences (JulSep,1996) of symptomatic
gastroesophageal reflux (GER), gastroesophageal reflux disease (GERD) and reflux esophagitis
(RE) among adult population in Beijing and Shanghai and to identify the risk factors of GERD.
Methods 5 000 residences of the two cities, age between 1870 were studied through
questionaire. Study was done by clustering sampling from city, surburban and rural areas using
simple random sampling. Symptom scores (Sc) of the intensity and frequency of heartburn, acid
reflux and regurgitation within one year at the time of study were taken as indices of acid reflux
(highest Sc=18) and Sc6 indicated the presence of symptomatic GER. A case control study was
also performed in some subjects from the survey to confirm the diagnosis of GERD and RE
using gastroscopy and 24h pH monitoring. An estimation of the prevalence of GERD and RE
was made on the basis of correct diagnostic rates of the diseases. Results (1) 4 992 subjects
completed the survey, 2.5% of the people had heartburn once a day, 448 people accounted for
8.97% of the population screened had symptomatic GER (Sc6), and male to female ratio was 11.
1. Estimated prevalences for GERD and RE were 5.77% and 1.92% respectively. (2) Stratified
analysis indicated that the prevalence of symptomatic GER in Beijing (10.19%) was higher than
that in Shanghai (7.76%), and there was also a higher prevalence of GER in male, in laboring
people and in people of rural areas in Beijing as compared with Shanghai. (3) Logistic analysis
indicated that GER had a close relatioship with dental, pharnyngolaryngeal disorders and
respiratory diseases, such as asthma and bronchitis, etc. Conclusions GERD is different in the
northern and southern area of China. Ratio between GERD and RE is 31 in our study. Age>40
(OR 1.01), greasy food (OR 6.56), big appetite (OR 1.99), tiredness (OR 2.35), emotional stress
(OR 2.22), pregnancy (OR 6.80) and constipation (OR 1.65) are the risk factors of GERD.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1999年第4期223-226,共4页
Chinese Journal of Digestion
基金
杨森科学委员会中国分会教育和科研基金
关键词
反流
胃食管反流病
反流性食管炎
流行病学
Gastroesophageal refluxGastroesophageal reflux diseaseReflux esophagitis