5-氨基酮戊酸光动力疗法联合咪喹莫特治疗基底细胞癌疗效观察

Observation on the efficacy of 5-aminolevulinic acid-photodynamic therapy combined with imiquimod for basal cell carcinoma

目的 评价5-氨基酮戊酸光动力疗法（ALA-PDT）与咪喹莫特联合治疗基底细胞癌的疗效.方法 将38例基底细胞癌患者随机分为两组,各19例.治疗组采用ALA-PDT与咪喹莫特联合治疗,对照组单用ALA-PDT.所有患者随访一年,观察两组疗效和复发率.结果 治疗组患者痊愈率为94.74%（18/19）,复发率为5.26%（1/19） 对照组痊愈率为68.42%（13/19）,复发率为31.58%（6/19）.两组痊愈率及复发率差异有统计学意义（x2=4.37,P〈0.05）.结论 ALA-PDT联合咪喹莫特治疗基底细胞癌在疗效及复发率方面均明显优于单用ALA-PDT.

Objective To evaluate the clinical efficacy of 5-aminolevulinic acid-photodynamic therapy （ALA-PDT） combined with imiquimod for basal cell carcinoma（ BCC）.Methods 38 patients with BCC were randomly divided into two groups.ALA-PDT plus imiquimod were given in the treatment group （19 patients） , and the control group（19 patients） were treated with only ALA-PDT.All patients were followed for one year,and the efficacy and relapse rate were observed.Results The cure rate and the recurrence rate of the treatment group was 94.74% （ 18/19） and 5.26% （1/19） .however,those of the control group was 68.42% （13/19） and 31.58% （6/19）.There was a statistical difference in the cure rate and recurrence rate between the two groups（x2 =4.37,P 〈0.05）.Conclusion The efficacy and relapse rate of ALA-PDT combined with imiquimod was much better than those of ALA-PDT only in treatment of BCC.